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. 2020 Apr 20;12(4):1012. doi: 10.3390/cancers12041012

Figure 1.

Figure 1

Immunohistochemical analysis of estrogen receptor alpha (ERα) and of somatostatin receptor 2 (SST2) expression in gonadotroph tumors using the immunoreactive score (IRS). IRS is calculated as the percentage of positive nuclei (0 to 4) × the intensity of the staining (0 to 3) (original magnification, ×200). (A). IRS ERα = 12 in a FSH-LH tumor (strong nuclear immunoexpression in 95% of neoplastic cells). (B). IRS ERα = 2 in a FSH-LH tumor (moderately intense immunopositivity in 5% of neoplastic cells). (C). IRS SST2 is negative in this FSH-LH tumor (absence of immunopositivity in the neoplastic cells; faint vascular expression as a positive internal control). (D). IRS SST2 = 12 in a FSH tumor (strong membranous immunoexpression in 100% of neoplastic cells). Abbreviations: follicle-stimulating hormone (FSH), luteinizing hormone (LH).