Figure 1.

(a) Schematic representation of the schedule of acetoxymethan/dextran sulfate sodium (AOM/DSS) application. Control mice were treated with AOM only, but no DSS was applied (not shown). (b) Mice of either wild type (WT) or H₄R^−/− (TM) genotype were treated either with AOM/DSS (CRC) or with AOM only (ctr). On the days indicated, clinical disease symptoms, body weight, perianal bleeding, and stool consistency, were monitored, graded by a scoring system, and summed up to the disease activity index (DAI). Means +/− SD of n = 2–6. *, p < 0.05 (two-way ANOVA with Sidak’s post hoc test).