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Beta-Tocotrienol remarkably up-regulates the pro-apoptotic protein expression of cytochrome c, increased caspase-3, and PARP-1 cleavages and downregulates Bcl-2 and two proliferation mediating proteins: p-PI3K and p-GSK3 in 24 h treated MDA-MB-231 cell lines. Western blot analysis of Bax, Bcl-2, p53, cytochrome C, cleaved PARP-1, cleaved caspase-3, p-PI3K, p-GSK3 and β-actin from untreated control and 10, 20 and 30 μM treated MDA-MB-231 breast cancer cells.
