Table 1.
Absolute values (in mm) for interventricular septum thickness (IVS), left ventricular posterior wall thickness (LVPW), left ventricular end-diastolic internal diameter (LVEDD) and left ventricular end-systolic internal diameter (LVESD), both at baseline and 14 days after reperfusion, in Cx43Cre-ER(T)/fl and Cx43fl/fl mice subjected to transient coronary occlusion.
| IVS | LVPW | LVEDD | LVESD | |||||
|---|---|---|---|---|---|---|---|---|
| Baseline | 14d | Baseline | 14d | Baseline | 14d | Baseline | 14d | |
| Cx43fl/fl + oil | 0.77 ± 0.02 | 0.80 ± 0.03 | 0.74 ± 0.02 | 0.73 ± 0.04 | 4.21 ± 0.16 | 4.59 ± 0.20 * | 2.82 ± 0.09 | 3.42 ± 0.19 * |
| (n = 8) | ||||||||
| Cx43fl/fl + 4-OHT | 0.77 ± 0.01 | 0.77 ± 0.02 | 0.75 ± 0.03 | 0.79 ± 0.01 | 4.17 ± 0.11 | 4.23 ± 0.17 | 2.93 ± 0.08 | 2.97 ± 0.15 |
| (n = 8) | ||||||||
| Cx43Cre/fl + oil | 0.77 ± 0.02 | 0.78 ± 0.02 | 0.74 ± 0.02 | 0.73 ± 0.02 | 4.02 ± 0.11 | 4.05 ± 0.10 | 2.70 ± 0.08 | 2.90 ± 0.09 * |
| (n = 10) | ||||||||
| Cx43Cre/fl + 4-OHT | 0.76 ± 0.02 | 0.79 ± 0.04 | 0.72 ± 0.02 | 0.71 ± 0.02 | 4.26 ± 0.26 | 4.26 ± 0.26 | 2.98 ± 0.15 | 3.09 ± 0.25 |
| (n = 7) | ||||||||
* (p < 0.05) indicates significant differences vs. corresponding baseline value (paired Student’s t test). Abbreviations: 14d: 14 days; 4-OHT: 4-hydroxytamoxifen; IVS: interventricular septum thickness; LVEDD: left ventricular end-diastolic internal diameter; LVESD: left ventricular end-systolic internal diameter; LVPW: left ventricular posterior wall thickness.