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. 2020 Apr 18;9(4):1008. doi: 10.3390/cells9041008

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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ECS-dependent interleukin release in AEC under constitutive and LPS-induced conditions. The picture summarizes the modulatory effect of ECS on pro- and anti-inflammatory interleukin expression and releasing profiles in the middle stage of gestation. The modulation of interleukin gene expression is indicated by means of different acid nucleic sizes. Changes in quantity of released/secreted interleukin proteins is indicated by different arrow sizes (upregulation and downregulation). (A) CB1 activation by agonist ACEA; (B) CB2 activation by agonist JWH-015 in the constitutive (blue panel) and LPS-induced (pink panel) conditions.