Figure 1.

Workflow of radiomics analysis. Manual delineation of representative tumor regions of interest (ROIs) using preoperative computed tomography (CT) (left panel). Radiomic features based on the first- and second-order statistics and two semantic features were computed using inner and outer ROIs. Features associated with postsurgical metastasis in pathologic stage I renal cell carcinoma were selected using the logistic least absolute shrinkage and selection operator (LASSO), and their prognostic values were evaluated using three classifiers (right panel).