Figure 1.

(A) Exemplar concentration–response (inhibition) curve analysis where the x-axis is the log QUB-1813 concentration (molar) and the y-axis the response (expressed as percentage inhibition calculated against the vehicle control value) for cockroach extract (CRE) trypsin-like protease (TLP) activity. (B) Summary table detailing the potency of candidate protease inhibitors tested against recombinant trypsin activity and the TLP activity present in CRE as assessed by fluorogenic peptide substrate-based assay. n ≥ 4.