Table 1.
OST subunits and their functions across three domains of life.
| Archaea | Bacteria | Yeast | Human | Function | |
|---|---|---|---|---|---|
| ssOST | ssOST | OST complex | OST-A complex | OST-B complex | |
| AglB | PglB | Stt3 | STT3A | STT3B | Catalytic activity |
| Ost4 | OST4 | OST4 | Maintains stability of catalytic sub-complex | ||
| Ost3/Ost6 | MAGT1|N33/TUSC3 | Oxidoreductase activity | |||
| Ost5 | TMEM258 | TMEM258 | Not clear | ||
| Ost1 | RPN1 | RPN1 | Restrains glycosylated peptide from sliding back to the catalytic site | ||
| Ost2 | DAD1 | DAD1 | Not clear | ||
| Wbp1 | OST48 | OST48 | Possibly LLO recruitment | ||
| Swp1 | RPN2 | RPN2 | Possibly LLO recruitment | ||
| KCP2 | Mediates interaction with translocon channel | ||||
| DC2 | Mediates interaction with translocon channel | ||||