. 2020 Apr 5;10(4):552. doi: 10.3390/biom10040552

Table 2.

Conformations of nucleosides and their analogues in the active sites of trimeric PNPs and MTAP.

Organism	Enzyme	Complex	PDB ID	Res. Ǻ	Ref.	Shape	P deg.	θ_m deg.	ν₂ deg.	χ deg.
Bos taurus	PNP; w.t.	Immucillin H, PO4	1B80	1.5	[30]	⁴T_O	239	29	−15	+133
H sapiens	MTAP; w.t.	MTA, SO4	1CG6	1.7	[48]	⁴T_O	241	32	−15	+126
M. tuberculesis	PNP; w.t.	Immucillin H, PO4	1G2O	1.75	[49]	₃T⁴	215	20	−16	+129
						⁴T₃	217	18	−15	+130
						₃T⁴	214	21	−17	+128
S. mansony	PNP; w.t.	Ino, and SO4 in monomers 1 and 3	3FAZ	1.9	[50]	⁴T_O	238	28	−15	+131
						₁T²	136	12	−8	+113
						⁴T_O	237	28	−16	+131
Calf splean	PNP; w.t.	Ino, SO4	1A9S	2.0	[51]	⁴T_O	243	27	−12	+133