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. 2020 Apr 17;12(4):997. doi: 10.3390/cancers12040997

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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High levels of ERBB4 are found in Group 4 medulloblastomas and are associated with poor clinical outcome. (A–D) Boxplot of the log2 of ERBB4 expression in the indicated medulloblastoma subgroups in (A) Northcott et al. (2012) cohort (n = 1087), (B) Robinson et al. (2012) cohort (n = 76), (C) Remke et al. (2011) cohort (n = 64), and (D) Cavalli et al. (2017) cohort (n = 612). (E) ERBB4 mRNA expression in the indicated medulloblastoma cell lines (n ≥ 3). (F,G) Kaplan–Meier curves for the Cavalli et al. (2017) cohort’s Group 4 patients’ and all patients’ overall survival rates based on ERBB4 expression obtained from hgserver1.