Table 3.
Multivariate analysis showing MCC-specific survival based on immune cells and biomarkers in the tumor microenvironment.
| Characteristics | Number of Patients (n) | Multivariate Analysis HR (95% CI) | p-Value |
|---|---|---|---|
| Presence of virus | 82 | 0.32 (0.13–0.78) | p = 0.01 |
| Presence of ulceration | 70 | 2.22 (0.99–4.98) | p = 0.05 |
| Lymphocytes (CD8, intratumoral) | 82 | 0.68 (0.54–0.85) | p = 0.001 |
| Neutrophils (CD66b, intratumoral) | 81 | 1.02 (0.82–1.26) | p = 0.87 |
| Neutrophil-to-lymphocyte ratio (CD66b/CD8, intratumoral) | 89 | 1.14 (1.00–1.31) | p = 0.04 |
| Endothelia (CD34, intratumoral) | 81 | 1.03 (0.86–1.23) | p = 0.77 |
| E-cadherin (intratumoral) | 81 | 0.98 (0.86–1.11) | p = 0.73 |
| PD-L1 (intratumoral) | 31 | 0.80 (0.53–1.20) | p = 0.29 |