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. 2020 Apr 21;12(4):1016. doi: 10.3390/cancers12041016

Table 1.

A list of completed research studies and clinical trials relating to the topic, arranged in alphabetical order.

Completed Research Studies and Clinical Trials
No. Study Title Condition(s) Intervention(s) Reference ClinicalTrials.gov Identifier
1. A Phase II Study of Epigenetic Therapy to Overcome Chemotherapy Resistance in Refractory Solid Tumors Refractory solid tumours Hydralazine and magnesium valproate [119] NCT00404508
2. Gene Expression Variation and Implant Wound Healing among Smokers and Diabetics - Smoking
- Diabetes
Dental implant surgery [120] NCT01663298
3. Histone Methyltransferase G9a and H3K9 Dimethylation Inhibit the Self-Renewal of Glioma Cancer Stem Cells Glioma Histone methyltransferase G9a and H3K9 dimethylation [121] N/A
4. Hydralazine and Valproate Plus Cisplatin Chemoradiation in Cervical Cancer Cervical cancer Hydralazine and magnesium valproate [122] NCT00404326
5. Phase I Study of MG98, an Oligonucleotide Antisense Inhibitor of Human DNA Methyltransferase 1, Given as a 7-Day Infusion in Patients with Advanced Solid Tumors Cancer MG98, an oligonucleotide to DNA DNMT1 [123] N/A
6. Non-Canonical PRC1.1 Targets Active Genes Independent of H3K27me3 and Is Essential for Leukemogenesis Acute myeloid leukaemia (AML) Downregulation of non-canonical PRC1.1 complex delays or prevents both carcinogenesis and its development in mice models [124] N/A
7. Study of Azacitidine in Adult Taiwanese Subjects with Higher-Risk Myelodysplastic Syndromes (MDS) Myelodysplastic syndromes Azacitidine [125] NCT01201811
8. The Linker Histone H1.0 Generates Epigenetic and Functional Intratumor Heterogeneity - Breast cancer
- Glioma and glioblastoma
- Melanoma
- Kidney renal papillary cell carcinoma
Liver cancer
Reversible-silencing of linker histone H1.0 to manipulate tumour proliferation [126] N/A
9. Vidaza to Restore Hormone Thx Prostate Prostate cancer Azacitdine for injectable suspension [127] NCT00384839