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Correlation of IDH1 mutation and cancer aggressiveness. Pathogenic IDH1 mutation depletes cellular metabolism through D-2-hydroxyglutarate (D-2-HG) production, which contributes to an aggressive phenotype in cancer cells. The mTORC2/Rac1 pathway and concomitant cytoskeleton mobilization promote cellular food-seeking, motility, chemotaxis, and endocytosis.
