Table 2.

SncRNAs associated with overall survival of MDS patients. Prediction model coefficients are applicable to the formula of survival risk score. The survival risk score of a total plasma sample = −0.631 × log₂ (level of miR-1260b) − 0.24 × log₂ (level of miR-328-3p) + 6.861. Similarly, the survival risk score of an EV sample = 0.615 × log₂ (level of miR-1237-3p) + 0.917 × log₂ (level of U33) − 0.106 × log₂ (level of hsa_piR_019420) − 1.01 × log₂ (level of miR-548av-5p) − 4.948. A sample is predicted as high (low) risk if its prognostic index is >0 (≤0).

sncRNA	Univariate Cox Regression Analysis			Prediction Model
	Univariate Cox Regression, p-Value	Permutation, p-Value	Hazard Ratio	Coefficient	Cross-Validation, p-Value
Total plasma
miR-1260b	0.0007	6 × 10−4	0.441	−0.631	0.0002
miR-3191-3p	0.0009	9 × 10−4	0.338	n.a.	n.s.
miR-328-3p	0.0009	8 × 10−4	0.474	−0.24	0.0008
EV fraction
miR-1237-3p	2 × 10−5	<1 × 10−7	20.135	0.615	5 × 10−7
U33	0.0006	6 × 10−4	2.499	0.917	0.0002
hsa_piR_019420	0.001	<1 × 10−7	20.135	−0.106	0.0008
miR-548av-5p	0.001	0.001	0.217	−1.01	0.0009

n.a.—not applicable, n.s.—nonsignificant.