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Different enzyme families and mechanisms of C5-uracil.
| Enzymes | Substrates | Coenzymes | Carbon Donor | Reducing Agent | Uracil Activation |
|---|---|---|---|---|---|
| TrmA RlmCD | tRNA (U54) rRNA (U747/1939) | none | SAM | none | Cysteine (Michael addition) |
| TrmFO RlmFO | tRNA (U54) rRNA (U1939) | FAD | CH2THF | NAD(P)H | Cysteine (Michael addition) |
| ThyA | dUMP | none | CH2THF | THF | Cysteine (Michael addition) |
| ThyX PolB | Dump UMP | FAD | CH2THF | NAD(P)H | Arginines (Polarization) |
