Figure 3.

Survival and the best tumor response in patients with EGFR T790M mutation. (A) Patients who received osimertinib following development of drug resistance and T790M detection. All patients had previously received 3–10 lines of treatment, and osimertinib was used based on detection of T790M mutation using the PNA clamping test. (B) Patients with late-stage disease who were diagnosed with T790M mutation (by PNA clamping test: n = 10; by PANAMutyper and cobas v2: n = 3) but did not receive osimertinib. Arrows indicate ongoing follow-up; diamonds indicate loss to follow-up. PR, partial response; CR, complete response; SD, stable disease; PD, progressive disease; NE, not evaluated; FU loss, loss to follow-up; ORR, objective response rate.