Table 1.
MMR mRNA and miRNA expression changes produced in Lung (NCI) and Head and Neck (FaDu) cancer cells exposed to high (2 μΜ) versus to low (1 μΜ) dose of NNK.
| Upper Aero-Digestive Tract Cancer Cell Lines | *2 μM vs. 1 μM of NNK |
|---|---|
| Lung cancer cells (NCI) | |
| MMR genes | |
| hMSH2 | 2.0 ↓ |
| hMLH1 | 1.6 ↓ |
| miRNAs | |
| miR-155 | 2.5 ↑ |
| miR-21 | 2.0 ↑ |
| miR-422a | 1.8 ↓ |
| Head and Neck cancer cells (FaDu) | |
| MMR genes | |
| hMSH2 | 5.7 ↓ |
| hMLH1 | 1.1 ↓ |
| miRNAs | |
| miR-155 | 1.1 ↑ |
| miR-21 | 1.8 ↑ |
| miR-422a | 1.0 |
* Fold-changes in normalized mRNA and miRNA levels (↓: decrease; ↑: increase)