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. 2020 Apr 22;12(4):1028. doi: 10.3390/cancers12041028

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Correlation between the expression of genes of the pre-replicative complex and telomerase levels. (a,c,e) Violin plots comparing the expression of TERT and the mean expression of genes in the: “Activation of the pre-replicative complex” pathway in paediatric High Grade Glioma (pHGG), Medulloblastoma and PNET. Samples were divided into three groups by K-means clustering. Pie chart plots show the percentage of samples (actual numbers are indicated) with H3F3A (dark green) or ATRX (light green) mutations for each of the three groups. No mutational data were reported for MB. (b,d,f) Scatter plots of pHGG, Medulloblastoma and PNET showing the expression of TERT (y-axis, in Z-score) vs. the expression of five genes (ORC4, CDC45, ORC6, RPA3, and MCM2) in the: “Activation of the pre-replicative complex” pathway (x-axis, in Z-score). Samples marked in different colors belong to the three different groups as clustered by K-means.

Correlation between the expression of genes of the pre-replicative complex and telomerase levels. (a,c,e) Violin plots comparing the expression of TERT and the mean expression of genes in the: “Activation of the pre-replicative complex” pathway in paediatric High Grade Glioma (pHGG), Medulloblastoma and PNET. Samples were divided into three groups by K-means clustering. Pie chart plots show the percentage of samples (actual numbers are indicated) with H3F3A (dark green) or ATRX (light green) mutations for each of the three groups. No mutational data were reported for MB. (b,d,f) Scatter plots of pHGG, Medulloblastoma and PNET showing the expression of TERT (y-axis, in Z-score) vs. the expression of five genes (ORC4, CDC45, ORC6, RPA3, and MCM2) in the: “Activation of the pre-replicative complex” pathway (x-axis, in Z-score). Samples marked in different colors belong to the three different groups as clustered by K-means.