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. 2020 Apr 8;12(4):913. doi: 10.3390/cancers12040913

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Modulation of glycolysis-associated metabolites by treatment with gracillin. H460 and H226B cells were treated with gracillin for 8 h. Cellular metabolic profiles associated with glycolysis and the pentose phosphate pathway were determined by LC/MS analysis. The bars represent the mean ± SD; * p < 0.05, ** p < 0.01, and *** p < 0.001, as determined by a two-tailed Student’s t-test by comparison with the vehicle-treated control group. Con: control; GRA: gracillin; G6P/F6P: glucose-6-phosphate/fructose-6-phosphate; FBP: fructose-1,6-bisphosphate; 3PG: 3-phosphoglycerate; PEP: phosphoenolpyruvate; PYR: pyruvate; 6PG: 6-phosphogluconate; R5P: ribulose-5-phosphate; R15BP: ribose-1,5-bisphosphate; S7P: sedoheptulose-7-phosphate; NADP: nicotinamide adenine dinucleotide phosphate; NADPH: reduced nicotinamide adenine dinucleotide phosphate.