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. 2020 Apr 8;12(4):913. doi: 10.3390/cancers12040913

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Antitumor effect of gracillin in vivo. (A,B) Antitumor effects of gracillin in tumor xenograft models established by inoculating MDA-MB-231 cells (A) and breast patient-derived tumor tissues (B) into mice. (C,D) Body weight changes in vehicle- or gracillin-treated mice. (E) Immunofluorescence analyses of cleaved caspase-3 (Cl-Cas3) expression in patient-derived xenograft (PDX) tumors from vehicle- and gracillin-treated mice. Scale bar: 20 μm. The bars represent the mean ± SD; ** p < 0.01 and *** p < 0.001, as determined by a two-tailed Student’s t-test by comparison with the vehicle-treated control group. Con: control; GRA: gracillin.