Figure 4.

The combined effects of paclitaxel (PTX) and 4D3 with tamoxifen (TAM) or bisphosphonate (BP) in vivo. A, B, Lung tumors of MDA‐468 cells (A) and MCF‐7 cells (B) in nude mice were treated with PTX (10 mg/kg BW)25 and/or TAM (500 mg/mouse)26 and/or 4D3 (1 mg/kg BW) on Days 1, 3 and 7. Fluorescence intensities of tumors 4 weeks after inoculation are displayed. C, D, Survivals of mice examined in panels A and B. E, F, Intratibial tumors of MDA‐468 cells (E) and MCF‐7 cells (F) in nude mice were treated with PTX (10 mg/kg BW)25 and/or BP (zoledronic acid, 100 μg/kg BW)28 and/or 4D3 (1 mg/kg BW) on Days 1, 3 and 7. Fluorescence intensities of tumors 4 weeks after inoculation are displayed. Error bar, standard deviation (SD) from five mice