Figure 4.

Prediction of prognosis of breast cancer patients. A, All human protein‐coding genes were evaluated using a series of methods (log‐rank test, meta‐analysis, machine learning with the random forest method and a neural network). The molecular Prognostic Score (mPS) based on 23 prognostic genes predicts the prognosis of breast cancer patients. B, mPS stratifies not only estrogen receptor (ER)‐positive but also ER‐negative patients, in contrast to existing methods such as MammaPrint and Oncotype. C, Chemotherapy may not be necessary for patients with a low mPS because their prognosis is fairly good