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. 2020 Apr 11;12(4):947. doi: 10.3390/cancers12040947

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Longitudinal measurements of SNVs. Longitudinal monitoring of SNVs in six patients with ALK, KRAS, and TP53 mutations by ddPCR during ALK TKI treatment. The x-axis indicates the time from the start of the treatment in days. The left y-axis indicates the mutant allele concentration of the SNV in copies/mL plasma, and the right y-axis shows the AF in percent. EML4-ALK rearrangement AFs from NGS analysis are plotted as well. Representative CT scan evaluations are indicated by gridlines, and ALK TKI treatments by shaded areas. PR, partial response; SD, stable disease; Mors, deceased; AF, allele frequency; ND, not detected; CNS, central nervous system; ddPCR, droplet digital PCR.