Table 2.
Diagnostic performance of plasma biomarkers for detection of nasopharyngeal carcinoma (NPC) (cut‐off = 0 copies/mL)
| Comparison | TP (n) | FN (n) | TN (n) | FP (n) | SE (%) | SP (%) | PPV (%) | NPV (%) | AUC |
|---|---|---|---|---|---|---|---|---|---|
| EBV DNA | |||||||||
| Early stage vs control | 128 | 10 | 222 | 21 | 92.8 | 91.4 | 85.9 | 95.7 | 0.921 |
| NPC vs control | 453 | 30 | 222 | 21 | 93.7 | 91.4 | 95.6 | 88.1 | 0.926 |
| miR‐BART7‐3p | |||||||||
| Early stage vs control | 133 | 5 | 235 | 8 | 96.4 | 96.7 | 94.3 | 97.9 | 0.965 |
| All NPC vs control | 464 | 19 | 235 | 8 | 96.1 | 96.7 | 98.3 | 92.5 | 0.964 |
| miR‐BART13‐3p | |||||||||
| Early stage vs control | 137 | 1 | 235 | 8 | 99.3 | 96.7 | 94.5 | 99.6 | 0.980 |
| All NPC vs control | 473 | 10 | 235 | 8 | 97.9 | 96.7 | 98.3 | 95.9 | 0.974 |
| All 3 nucleic acid species combined | |||||||||
| Early stage vs control | 137 | 1 | 242 | 1 | 99.3 | 99.6 | 99.3 | 99.6 | 0.994 |
| All NPC vs control | 471 | 13 | 242 | 1 | 97.5 | 99.6 | 99.7 | 94.9 | 0.997 |
Abbreviations: AUC, area under the receiver operating characteristic curve; EBV, Epstein‐Barr virus; FN, false negative; FP, false positive; miR‐BART, BamHI A rightward transcripts (BART) encoded microRNA; NPV, negative predictive value; PPV, positive predictive value; SE, sensitivity; SP, specificity; TN, true negative; TP, true positive.