Table 4.
Univariate and multivariable analysis for disease‐free survival
| Variables | Univariate analysis | Multivariate analysis | ||
|---|---|---|---|---|
| HR (95%CI) | P‐value | HR (95%CI) | P‐value | |
| Age, ≥50 y | 1.206 (0.829‐1.754) | .328 | ||
| Sex, male | 1.709 (0.832‐3.511) | .145 | ||
| HBsAg, positive | 1.361 (0.662‐2.796) | .402 | ||
| AFP, ≥400 ng/mL | 1.614 (1.110‐2.348) | .012 | 1.173 (0.791‐1.738) | .428 |
| Total bilirubin, >17.1 μmol/L | 1.015 (0.630‐1.633) | .953 | ||
| Albumin, ≥35 g/L | 0.542 (0.134‐2.196) | .391 | ||
| ALT, >44 U/L | 1.717 (1.179‐2.502) | .005 | 1.791 (1.179‐2.721) | .006 |
| Tumor diameter, ≥5 cm | 2.234 (1.443‐3.458) | <.001 | 1.315 (0.803‐2.154) | .277 |
| Number of tumors, multiple | 1.936 (1.138‐3.291) | .015 | 1.219 (0.680‐2.183) | .506 |
| Tumor capsulation, full | ||||
| Tumor capsulation, incomplete | 1.551 (0.982‐2.450) | .060 | ||
| Tumor capsulation, no | 1.596 (1.019‐2.500 | .041 | 1.064 (0.619‐1.829) | .822 |
| PVTT, positive | 2.083 (1.239‐3.502) | .006 | 1.321 (0.664‐2.629) | .427 |
| Microvascular invasion, positive | 2.502 (1.713‐3.652) | <.001 | 1.888 (1.216‐2.932) | .005 |
| EVA1, high expression | 3.347 (2.196‐5.102) | <.001 | 2.697 (1.710‐4.253) | <.001 |
P <.05 is shown in bold.
Abbreviations: AFP, α‐fetoprotein; ALT, alanine aminotransferase; HBsAg, Hepatitis B surface antigen; PVTT, portal vein tumor thrombus.