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. 2020 Apr 9;12(4):929. doi: 10.3390/cancers12040929

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Febuxostat does not compromise the cytotoxic effects of Dox on multiple myeloma (MM) cells. (A) The MM cell lines RPMI82266, U266, OPM-2, and MM.1S were cultured in triplicate with the indicated concentrations of Dox and febuxostat (Febu) for 48 h. The cell viability was measured by the WST-8 cell proliferation assay. Results are expressed as mean ± SD. (B) RPMI82266 and MM.1S MM cells were cultured with the indicated concentrations of Dox and Febu for 24 h. Caspase 3 and cleaved caspase 3 protein levels were analyzed by Western blotting. β-actin served as a loading control. (C) RPMI8226 and U266 MM cells were cultured in triplicate with the indicated concentrations of Dox and/or NAC for 48 h. The cell viability was analyzed by the WST-8 cell proliferation assay. Results are expressed as mean ± SD.

Febuxostat does not compromise the cytotoxic effects of Dox on multiple myeloma (MM) cells. (A) The MM cell lines RPMI82266, U266, OPM-2, and MM.1S were cultured in triplicate with the indicated concentrations of Dox and febuxostat (Febu) for 48 h. The cell viability was measured by the WST-8 cell proliferation assay. Results are expressed as mean ± SD. (B) RPMI82266 and MM.1S MM cells were cultured with the indicated concentrations of Dox and Febu for 24 h. Caspase 3 and cleaved caspase 3 protein levels were analyzed by Western blotting. β-actin served as a loading control. (C) RPMI8226 and U266 MM cells were cultured in triplicate with the indicated concentrations of Dox and/or NAC for 48 h. The cell viability was analyzed by the WST-8 cell proliferation assay. Results are expressed as mean ± SD.