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. 2020 Apr 3;12(4):868. doi: 10.3390/cancers12040868

Figure 2.

Figure 2

High expression of TIE2 in the primary tumor of breast cancer patients is associated with increased overall survival. Analysis of overall survival using the PROGgene database. The median TIE2 mRNA level in the primary tumor was taken as a bifurcation point. Results are presented as (A) Kaplan–Meyer plots for the Pawitan (GSE1456) and Miller datasets (GSE3494), or as (B) a forest plot, indicating the overall hazard ratio (HR) for metastasis-occurrence and 95% confidence interval (CI). The horizontal line divides datasets with a HR higher or lower than 1, the dotted lines separate the datasets with a HR lower than 0.85 and higher than 1.15. Survival analysis was performed using a log-rank test, ‡ p < 0.078, and ** p < 0.01.