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TIE2 expression increases the resistance to 5-Fluorouracil in MCF-7 cells. MCF-7 TIE2tet and MCF-7 eGFPtet cells were cultured in the presence or absence of doxycycline (1 µg/mL) during 10 days of the experiment. 5-Fluorouracil (5-FU) was added to the cells for 4 days. Proliferation was assessed by MTT, and values are represented as the average ± SEM. *** p < 0.001 vs. vehicle-treated cells and analyzed using a two-way ANOVA with Bonferroni post-test.
