Table 3.
Crude Alzheimer’s disease mortality rates and mortality rate ratios (MRR) for breast cancer patients from SEER (Surveillance, Epidemiology, and End Results) 13 for different chemotherapy statuses. Mortality rates and MRRs were not calculated for subgroups with O < 10.
| Age at Diagnosis (Years) |
Time since BC Diagnosis (Months) |
Chemotherapy Status | Crude MRR | CI95 c | p-Value d | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| No/Unknown | Yes | |||||||||||
| O a | Persons | Person-Years | Crude AD Mortality Rate b |
O a | Persons | Person-Years | Crude AD Mortality Rate b | |||||
| 65–69 | 0–119 | 57 | 24,703 | 154,178.79 | 36.97 | 10 | 10,286 | 55,654.87 | 17.97 | 0.486 | 0.221–0.960 | 0.0315 |
| 120+ | 205 | 8748 | 50,105.53 | 409.14 | 37 | 2541 | 11,404.05 | 324.45 | 0.793 | 0.543–1.130 | 0.1931 | |
| Total | 262 | 24,703 | 204,284.32 | 128.25 | 47 | 10,286 | 67,058.92 | 70.09 | 0.547 | 0.392–0.748 | 0.0001 | |
| 70–74 | 0–119 | 127 | 23,885 | 147,381.40 | 86.17 | 14 | 6182 | 31,469.60 | 44.49 | 0.516 | 0.274–0.899 | 0.0168 |
| 120+ | 387 | 8111 | 40,853.18 | 947.29 | 43 | 1310 | 5474.60 | 785.45 | 0.829 | 0.590–1.138 | 0.243 | |
| Total | 514 | 23,885 | 188,234.58 | 273.06 | 57 | 6182 | 36,944.21 | 154.29 | 0.565 | 0.422–0.744 | <0.0001 | |
| 75–79 | 0–119 | 296 | 21,724 | 127,501.65 | 232.15 | 19 | 3191 | 15,014.76 | 126.54 | 0.545 | 0.324–0.867 | 0.0092 |
| 120+ | 339 | 6007 | 24,295.26 | 1395.33 | 23 | 549 | 1898.00 | 1211.80 | 0.869 | 0.543–1.325 | 0.512 | |
| Total | 635 | 21,724 | 151,796.92 | 418.32 | 42 | 3191 | 16,912.76 | 248.33 | 0.594 | 0.424–0.812 | 0.0009 | |
| 80–84 | 0–119 | 420 | 16,205 | 82,793.72 | 507.28 | 13 | 1179 | 4695.96 | 276.83 | 0.546 | 0.288–0.943 | 0.029 |
| 120+ | 213 | 2796 | 8314.72 | 2561.72 | 8 | 118 | 304.28 | N/A | N/A | N/A | N/A | |
| Total | 633 | 16,205 | 91,108.44 | 694.78 | 21 | 1179 | 5000.25 | 419.98 | 0.605 | 0.372–0.932 | 0.0218 | |
| 85–89 | 0–119 | 308 | 9267 | 38,241.96 | 805.4 | 5 | 293 | 843.2 | N/A | N/A | N/A | N/A |
| 120+ | 54 | 786 | 1740.11 | 3103.25 | 0 | 7 | 12.25 | N/A | N/A | N/A | N/A | |
| Total | 362 | 9267 | 39,982.07 | 905.41 | 5 | 293 | 855.45 | N/A | N/A | N/A | N/A | |
| 90–94 | 0–119 | 104 | 3261 | 9809.39 | 1060.21 | 0 | 57 | 124.03 | N/A | N/A | N/A | N/A |
| 120+ | 6 | 67 | 97.48 | N/A | 0 | 0 | 0 | N/A | N/A | N/A | N/A | |
| Total | 110 | 3261 | 9906.86 | 1110.34 | 0 | 57 | 124.03 | N/A | N/A | N/A | N/A | |
| 95–99 | 0–119 | 25 | 640 | 1513.91 | 1651.35 | 0 | 8 | 25.25 | N/A | N/A | N/A | N/A |
| 120+ | 0 | 3 | 1.25 | N/A | 0 | 0 | 0 | N/A | N/A | N/A | N/A | |
| Total | 25 | 640 | 1515.16 | 1649.99 | 0 | 8 | 25.25 | N/A | N/A | N/A | N/A | |
a Number of deaths due to Alzheimer’s disease. b Rate per 100,000 person-years. c 95% Confidence interval. d From a test-based method.