Table 7.
Summary of huntingtin PTMs and propensity for protein aggregation.
| Post-Translational Modification | Residues Modified | Author & Year | Aggregation | Formation of Oligomers | Formation of Fibrillar Aggregates | Formation of Amorphous Aggregates |
|---|---|---|---|---|---|---|
| Acetylation | K6, K9, K15 ‡ | Chaibva et al., 2016 [155] | Decrease | Decrease | - | |
| Phosphorylation | T3 * | Chiki et al., 2017 [156] | Decrease | - | Decrease | - |
| T3 | Ansaloni et al., 2014 [157] | Decrease | Decrease | Decrease | - | |
| T3 * | Cariulo et al., 2017 [158] | Decrease | - | - | - | |
| S13, S16, S13/S16 † | DeGuire et al., 2018 [159] | Decrease | Increase | Decrease | - | |
| Pseudo-phosphorylation | S13, S16 † | DeGuire et al., 2018 [159] | Decrease | Increase | Decrease | - |
| S13/S16 * | Gu et al., 2009 [160] | Decrease | - | Decrease | - | |
| Proteolytic Cleavage | Cleavage site between residue 104 and 114 * | Lunkes et al., 2002 [161] | Increase | - | - | - |
* Mutant huntingtin protein was used in this study. † Wild-type and mutant huntingtin protein were used in this study. ‡ Wild-type and truncated huntingtin protein were used in this study.