Figure 6.
KDM4A expression positively correlates with USP1 expression in clinical prostate cancer (PC) samples. A, Expression of USP1 and KDM4A in androgen receptor (AR)‐positive (RV1, C42B, LNCAP, VCAP, and LN95) and AR‐negative cells (PC3 and DU145) was analyzed by western blot. B, A subset of prostate tumor (T) and normal tissues (N) were subjected to western blotting, to examine USP1 and KDM4A protein levels. C, Representative staining of USP1 and KDM4A in PC and normal prostate tissues. D, Quantification of USP1 and KDM4A protein levels in normal and PC tissues, and the correlation study of USP1 and KDM4A expression level in prostate carcinoma. Statistical analyses were undertaken with the χ2 test, P < .001. R, Pearson’s correlation coefficient