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Knockdown of sphingosine kinase restores NKT cell responses to MCL. (A) Human NKT cells were co-cultured with SP53 and SK1-KD cells and NKT cell activation, as determined by IFN-γ production, was measured by ELISA. (B) NKT cell specific lysis of SP53, SK1-KD1, and SK1-KD2 was assessed by standard 51Cr-release assay. (C) CD1d expression on SP53, SK1-KD1, and SK1-KD2 cell lines was determined by flow cytometry. Data was analyzed by one-way ANOVA. ** p < 0.001; *** p < 0.0001.
