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Plasma membrane injury inflicted by UV-laser ablation injury. (A) Schematic of ablation laser injury to monitor annexin behavior during plasma membrane repair. Ca2+ influx through the wounded membranes activates and enables annexin to bind and seal the hole by bending membrane and glue membrane edges together. (B) Sequential images from time-lapse movie of a MCF-7 breast carcinoma cell showing translocation behavior of ANXA4-RFP to the site of damage (white arrow) upon laser injury.
