Figure 5.

The altered transcriptional signature of every individual sample can be represented by a sample-specific barcode. (A) Frequency of expression of the different unbalanced processes in non-demented vs. AD samples. The graph shows that the seven unbalanced processes identified by surprisal analysis (SA) are each active in a similar percentage of non-demented vs. AD-bearing samples, and none can distinguish between the types of samples. (B) Sample-specific barcodes enable characterization of the complete altered transcriptional signature in every sample. The barcodes that characterize the three samples from Figure 4 are exemplified here. The sample-specific barcodes denote which unbalanced processes are active in the sample, including the sign of the amplitude.