Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
The role of macrophages in tumor development and bone metastases. The bone microenvironment is a “rich soil” for tumor growth. Tumor associated macrophage polarization towards the M2 phenotype promotes the development of the metastatic cascade that contributes to the development of skeletal metastases once the bone is colonized by metastatic cancer cells. Various immunotherapeutic strategies are currently under clinical trials in order to find effective treatments.
