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. 2020 Apr 10;10(4):585. doi: 10.3390/biom10040585

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Deletion of VDAC1 induces mitochondrial fission in non-injured and ischemia-injured renal cortex. Protein levels of dynamin-related protein 1 (DRP1) on days 1 and 7 of recovery after bilateral renal ischemia (IR) in WT (a) and VDAC1 KO mice (b). (c) Densitometric analysis of the immunoblots shown in (a) and (b). The blots represent renal cortical mitochondria obtained from sham-operated animals and four mice sacrificed on day 1 (IR-day 1) and 3 mice sacrificed on day 7 (IR-day 7) post reperfusion in three different experiments. * Values significantly different (p < 0.05) from the mitochondria of respective WT mice.