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Structure and inhibitors of the immunoproteasome complex. In immunoproteasome, β5 (PSMB5), β1 (PSMB6), and β2 (PSMB7) of the constitutive proteasome complex are replaced by their respective inducible counterparts β5i (LMP7) β1i (LMP2), and β2i (MECL-1), under inflammatory conditions and certain pathological states, including cancer. ONX-0914, PR-924 and KZR-616 are reported as selective inhibitors of immunoproteasome (Table 3).
