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. 2020 Apr 13;10(4):233. doi: 10.3390/brainsci10040233

Figure 1.

Figure 1

P-cresol enhances anxiety-like behaviors, stereotypies, locomotor parameters and hinders social preference in BTBR mice. (A) Total entries, % of time spent and entries in open arms in the Elevated Plus Maze. (B) Distance travelled and speed in the Open Field Test after acute p-cresol treatment. (C) Schematic representation of the Object Recognition Test. (D) Time spent grooming during the first session of the Object Recognition Test. (E) Time spent exploring the novel or familiar object during the test session of the Object Recognition Test. (F) Schematic representation of the three-chamber Social Interaction Test. (G) Time in object and subject zones during the Social Interaction Test session. (H) Time spent in contact with the object or with the social intruder during the Social Interaction Test. Results are shown as mean ± sem. *, **, *** p < 0.05, p < 0.01, p < 0.001 P-C1 or P-C10 vs. CNTR. ^^ p < 0.01 P-C10 vs. P-C1, ## p < 0.01 old vs. new, §§, §§§ p < 0.01, p < 0.001 subject vs. object.