Table 1.
Neurochemical analysis of monoamine and metabolite levels (ng/g wet weight) assessed in medial prefrontal cortex, hippocampus, amygdala, caudate putamen and nucleus accumbens.
| DA | DOPAC | HVA | NE | 5HT | HIAA | ||
|---|---|---|---|---|---|---|---|
| pFC | CNTR | 342.95 ± 99.78 | 44.96 ± 9.21 | 43.95 ± 7.91 | 179.12 ± 26.24 | 826.28 ± 116.29 | 266.67 ± 51.36 |
| P-C1 | 305.53 ± 57.11 | 43.79 ± 11.19 | 37.07 ± 6.91 | 132.30 ± 25.35 | 607.64 ± 74.63 | 152.62 ± 15.13 | |
| P-C10 | 423.87 ± 138.8 | 76.9 ± 24.84 | 42.91 ± 14.9 | 139.42 ± 36.39 | 881.03 ± 207.31 | 171.06 ± 39.93 | |
| HIPP | CNTR | 155.18 ± 15.24 | 41.73 ± 15.71 | 29.98 ± 2.79 | n.d. | 641.22 ± 173.86 | 378.98 ± 59.82 |
| P-C1 | 113.92 ± 26.27 | 21.54 ± 7.92 | 22.77 ± 3.72 | n.d. | 425.17 ± 92.36 | 327.61 ± 102.74 | |
| P-C10 | 119.47 ± 40.91 | 37.29 ± 12.97 | 30.65 ± 7.65 | n.d. | 365.6 ± 145.62 | 314.2 ± 99.42 | |
| AMY | CNTR | 858.36 ± 112.78 | 68.98 ± 6.62 | 57.41 ± 11.05 | 274.34 ± 103.69 | 193.46 ± 42.02 | 149.84 ± 55.3 |
| P-C1 | 2292.71 ± 526.75 * | 187.95 ± 38.11 * | 122.05 ± 26.41 * | 314.18 ± 89.95 | 356.62 ± 109.27 | 212.38 ± 88.17 | |
| P-C10 | 2197.45 ± 992.31 * | 179.38 ± 30.12 * | 140.21 ± 23.75 * | 283.15 ± 48.49 | 330.85 ± 59.27 | 226.03 ± 36.56 | |
| CP | CNTR | 5284.18 ± 1015.8 | 584.97 ± 186.65 | 251.81 ± 33.64 | 35.46 ± 8.61 | 159.61 ± 31.77 | 133.99 ± 28.56 |
| P-C1 | 5499.14 ± 842.38 | 327.32 ± 56.27 | 240.48 ± 43.35 | 46.41 ± 8.61 | 183.88 ± 31.09 | 130.22 ± 38.39 | |
| P-C10 | 16270.59 ± 2153.37 ***,### | 1176.26 ± 223.34 ***,### | 658.32 ± 97.93 ***,### | 63.11 ± 12.83 | 341.1 ± 34.82 **,## | 242.73 ± 49.04 | |
| NAc | CNTR | 5623.89 ± 1050.64 | 506.55 ± 91.15 | 412.55 ± 87.32 | 1214.04 ± 390.84 | 1191.69 ± 355.05 | 459.72 ± 126.19 |
| P-C1 | 5035.05 ± 1134.2 | 504.3 ± 119.73 | 276.01 ± 49.36 | 1359.63 ± 200.81 | 1232.82 ± 357.02 | 305.25 ± 63.12 | |
| P-C10 | 16156.11 ± 1812.97 **,## | 1698.82 ± 325.04 **,## | 817.35 ± 91.08 *,## | 1883.69 ± 626.27 | 1360.47 ± 512.3 | 480.62 ± 189.73 |
Data are shown as mean ± sem. Highlighted in bold, significant effects of group x amine or metabolite. CNTR, n = 9; P-C1, n = 6; P-C10, n = 6. *, **, ***p < 0.05, 0.01, 0.001 P-C1 or P-C10 vs. CNTR. #, ##, ### p < 0.05, 0.01, 0.001 P-C10 vs. P-C1.