Table 1.
Subunits and function of the human 26S proteasome.
| Subunits | Function |
|---|---|
| RP lid subcomplex | |
| RPN3, RPN5, RPN6, RPN7, RPN9, RPN12, DSS1 | Structural |
| RPN8 | Dimerization with RPN11 MPN |
| RPN11 | Deubiquitinase |
| RPN10 | Ubiquitin receptor |
| RP base subcomplex | |
| RPN1 | Ubiquitin receptor/USP14 binding |
| RPN2 | Structural |
| RPN13 | Ubiquitin receptor/UCH37 binding |
| RPT1-RPT6 | AAA+ ATPase |
| CP subcomplex | |
| α1-α7 | CP gate |
| β1, β2, β5 | Proteolytic chamber, peptide hydrolysis |
| β3, β4, β6, β7 | Proteolytic chamber |
| Non-stoichiometric | |
| USP14, UCH37 | Deubiquitinase |