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. 2020 Apr 1;12(4):855. doi: 10.3390/cancers12040855

Table 3.

Studies of plant extracts for the biosynthesis of anticancer AgNPs (brain, cervical and colon cancers cell lines).

Cancer Plant Part Used NP Size/NP Shape Incubation Time Cell Line IC50 Ref.
Brain Cancer Butea monosperma Leaf 20–80 nm/spherical 2 h HNGC2 Dose dependent [101]
Cervical Cancer Azadirachta indica Leaf 2–18 nm/triangular, hexagonal - Siha ≤4.25 μg/mL [106]
Acorous calamus Rhizome 31.86 nm/spherical 20 h HeLa Dose dependent [107]
Azadirachta indica Leaf <40 nm/spherical 6 h Dose dependent [95]
Calotropis gigantea Latex 5–30 nm/spherical 24 h Dose dependent [108]
Cymodocea serrulata Whole 17–29 nm/spherical 2 h 107.7 (GI50) [109]
Heliotropium indicum Leaf 80–120 nm/spherical 2 h 20 μg/mL [110]
Melia azedarach Leaf 78 nm/cubical, spherical 10 min 300 μg/mL (LD50) [23]
Moringa olifera Stem bark 38–40 nm/spherical, pentagonal 24 h Dose dependent [25]
Podophyllum hexandrum Leaf 14 nm/spherical 30–150 min 20 μg/mL [111]
Sargassum vulgare (algae) Whole 10 nm/spherical 3 h Dose dependent [112]
Syzygium cumini Flower <40 nm/spherical 6 h Dose dependent [95]
Colon Cancer Plumeria alba Flower 36.19 nm/spherical 30 min COLO 205 5.5 μg/mL [113]
Rosa indica Petal 23.52–60.83 nm/spherical 1 h HCT 15 30 μg/mL [114]
Vitex nigundo Leaf 22 nm/spherical 4 h 20 μg/mL [115]
Citrullus colocynthis Leaf 13.37 nm/spherical 24 h HCT-116 >30 μg/mL [103]
Roots 7.39 nm/spherical 24 h >30 μg/mL
Seeds 16.57 nm/Spherical 24 h >30 μg/mL
Fruit 19.26 nm/spherical 24 h 21.2 μg/mL
Commelina nudiflora L. Whole 24–80 nm/spherical, triangular 24 h 100 μg/mL [61]
Gymnema sylvestre Leaf -/spherical 24 h HT29 85 μg/mL [116]
Ulva lactuca (algae) Whole 56 nm/spherical 10 min 49 μg/mL [105]

NP—nanoparticle.