Figure 1.

In vitro trastuzumab-mediated growth inhibition of (A) SKOV3.IP1 cells, naturally expressing high HER2 levels and (B) 231Br cells, stably transfected to express high levels of HER2. Cells were cultured with different trastuzumab concentrations from day 0–5, followed by trastuzumab-free medium at day 6–10. Concentration-dependent growth inhibition can be observed for SKOV3.IP1 cells during trastuzumab treatment. 231Br cell growth was not hampered, regardless of trastuzumab concentration. (ns: not significant, ** p < 0.01, *** p < 0.005).