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. 2020 Apr 16;12(4):983. doi: 10.3390/cancers12040983

Figure 5.

Figure 5

Immune-compromised SS IL2RG−/− male and female rats receiving localized high-dose cardiac RT have echocardiogram parameters revealing worse heart function compared to SS WT rats. SS WT and IL2RG−/− rats were given 24 Gy × 1 localized cardiac RT and echocardiograms were performed, which revealed that the left-ventricular internal diameter at end-diastole (LVIDd) (A: female; B: male) and at end-systole (LVIDs) (C: female; D: male) were significantly increased at three months post-RT in SS IL2RG−/− versus SS WT rats, indicating worse function. In male rats, the significantly elevated LVIDs persisted at five months. End-systolic volume (ESV) was not significantly different in female rats, (E) but ESV was significantly elevated at three months post-RT in male IL2RG−/− versus WT rats (F), which can be associated with worse cardiac function. In females, poorer ejection fraction (EF) (G) and fractional shortening (FS) (I) values were seen in the IL2RG−/− versus WT rats post-RT (not statistically significant). In males, EF (H) and FS (J) were significantly decreased in IL2RG−/− rats at three months post-RT, and FS remained decreased at five months, indicating poorer function. Stroke volume (SV) was not significantly different in (K) female or (L) male rats at any time point. Values are means ± SEM; n = 9–15 rats/group, * p < 0.05, # p < 0.01.