Table 2.
Diagnostic accuracy of KYNA and KYNA/TRP in CSF.
| CSF KYNA | CSF KYNA/TRP | ||||||
|---|---|---|---|---|---|---|---|
| MCI/AD Aβ+ vs. Control Aβ− | MCI/AD Aβ+ vs. FTD/ALS/PSP Aβ− | Aβ+ vs. Aβ− | MCI/AD Aβ+ vs. Control Aβ− | MCI/AD Aβ+ vs. FTD/ALS/PSP Aβ− | Aβ+ vs. Aβ− | ||
| AUC | 0.807 | 0.734 | 0.770 | AUC | 0.754 | 0.659 | 0.715 |
| (95% CI) | (0.716, 0.897) | (0.639, 0.828) | (0.691, 0.848) | (95% CI) | (0.641, 0.867) | (0.543, 0.776) | (0.622, 0.802) |
| Sensitivity, % | 60.00 | 60.00 | 60.00 | Sensitivity, % | 66.67 | 66.67 | 66.67 |
| Specificity, % | 82.61 | 87.50 | 85.11 | Specificity, % | 72.73 | 60.00 | 67.57 |
| Accuracy, % | 64.81 | 66.06 | 68.94 | Accuracy, % | 67.96 | 65.63 | 66.95 |
| Cut-off, µg/L | 7.56 | 7.56 | 7.56 | Cut-off, µg/L | 0.068 | 0.068 | 0.068 |
| p # | <0.05 | ns | <0.05 |
Performance of KYNA (left) and ratio KYNA/TRP (right) in CSF analyzed by receiver operating characteristic (ROC) curve. # p-value indicates statistical difference between KYNA and KYNA/TRP ROC curves. Abbreviations: MCI, mild cognitive impairment; AD, Alzheimer’s disease dementia; FTD, frontotemporal dementia; ALS, amyotrophic lateral sclerosis; PSP, progressive supranuclear palsy; Aβ+, AD CSF biomarker profile; Aβ− non-AD CSF biomarker profile; AUC, area under the curve; ns, non-significant.