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. 2020 Apr 21;10(4):639. doi: 10.3390/biom10040639

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Meridianins and lignarenone B up-regulate neurite complexity in vitro. (A) Representative MAP2 images obtained by epifluorescent microscopy from primary cortical neurons treated with vehicle or meridianins 10 μM. Scale bar, 40μm. (B) Sholl analysis from MAP2-positive neurons (two-way ANOVA analysis; interaction effect, number of dendrites, F_{7, 536} = 55.91, p < 0.001). n = 45–55 neurons per condition. (C) Representative MAP2 images obtained by epifluorescent microscopy from primary cortical neurons treated with vehicle or lignarenone B 10μM. Scale bar, 40μm. (D) Sholl analysis from MAP2-positive neurons (two-way ANOVA analysis; interaction effect, F_{7, 815} = 7.247, p < 0.0001; group effect, F_{7, 815} = 67.90, p < 0.0001; number of dendrites, F_{7, 815} = 72.51, p < 0.0001). n = 45–5 neurons per condition. *** p < 0.001 and **** p < 0.0001 when compared with Vehicle.