Figure 8.

Brigatinib (A) and a ball-and-stick representation of brigatinib (B). Brigatinib has a dimethylphosphine oxide (DMPO) group, a feature not found in other ALK inhibitors. The solubilization group imparts a high water solubility and low lipophilicity to brigatinib. The colors of the element symbols in the structural formula (A) correspond to the colors of the elements in the ball-and-stick representation. Only the hydrogen molecule is shown in black in the structural formula, and in white in the ball-and-stick model.