Table 4.
Cytotoxic activity of compounds 1–5.
| Cell Lines | IC50 (µM) | |||||
|---|---|---|---|---|---|---|
| Compounds | Epothilone B | |||||
| 1 | 2 | 3 | 4 | 5 | ||
| HeLa cells KB3.1 | 29.7 | 3.9 | 17.2 | - | - | 8.9 × 10−5 |
| Mouse fibroblast L929 | 50.0 | 14.1 | - | - | - | 1.8 × 10−3 |
The in vitro cytotoxicity test of polyketides 1–5 was conducted against two mammalian cell lines, with epothilone B as positive control. Starting concentration for cytotoxicity assay was 66 μg/mL, substances were dissolved in MeOH (1 mg/mL). MeOH was used as negative control and showed no activity against the tested mammalian cell lines. Results were expressed as IC50: half maximal inhibitory concentration (µM). (-): no inhibition.