Figure 3.

The integrative ROC curve for estimation of the diagnostic value of diabetic fetopathy in patients with T2DM or GDM complicated gestation using CEACAM1, CNDP1, CRP, IgG4 and IgA2 proteins. The integral AUC = 0.893 at 95% CI, 0.785–0.980. The least valuable protein is CRP caused by its highly sensitive fluctuations in response to impairments in many biologic processes (indicated in the figure insert). However, elimination of CRP from the proposed panel erodes the integral auROC to 0.813 (at 95% CI), hence CRP can be considered as an auxiliary marker among other more specific proteins in the panel. The proper combination of proteins in an appropriate quantitative range may endorse the ability of sensitive recognition of DF.