Table 1.
Clinical and histopathological characteristics of breast cancer (BC) patients studied. Prognostic marker classification and IHC-surrogate subtype definition were established following St. Gallen and ASCO/CAP guideline recommendations.
| Characteristics | ER + n (%) | ER − n (%) | P Value (Fisher Test) | |
|---|---|---|---|---|
| Total number of patients | 47 | 9 | - | |
| Median age (Interval) | 62 (35–82) | 60 (43–78) | 0.591 * | |
| Tumor Size (missing 1 case) | <20 mm | 17 (36.2) | - | 0.028 |
| ≥20 mm | 30 (63.8) | 9 (100) | ||
| Metastatic Lymph nodes | pN0 | 22 (46.8) | 7 (77.8) | 0.230 |
| pN1–3 | 14 (29.8) | 1 (11.1) | ||
| pN > 3 | 11 (23.4) | 1 (11.1) | ||
| Grading | 1 | 4 (8.5) | - | 0.085 |
| 2 | 20 (42.6) | 1 (11.1) | ||
| 3 | 23 (48.9) | 8 (88.9) | ||
| Histotype | IDC-NST | 36 (76.6) | 5 (55.6) | 0.245 |
| ILC | 2 (4.3) | - | ||
| Mixed type | 5 (10.6) | - | ||
| others | 4 (8.5) | 4 (44.4) | ||
| Vascular invasion | No | 7 (14.9) | 3 (33.3) | 0.192 |
| Yes | 40 (85.1) | 6 (66.7) | ||
| PgR | 0 | 17 (36.2) | 9 (100) | <0.0001 |
| ≥1 | 30 (63.8) | - | ||
| Ki67 | <20% | 14 (29.8) | 1 (11.1) | 0.235 |
| ≥20% | 33 (70.2) | 8 (88.9) | ||
| HER2 | Negative | 36 (76.6) | 6 (66.7) | 0.399 |
| Positive | 11 (23.4) | 3 (33.3) | ||
| AR | 0 | 6 (12.8) | 3 (33.3) | 0.148 |
| ≥1% | 41 (87.2) | 6 (66.7) | ||
| IHC – Surrogate Subtype |
Luminal A-Like | 12 (25.5) | - | <0.0001 |
| Luminal B-Like (HER2-) | 24 (51.1) | - | ||
| Luminal B-Like (HER2+) | 11 (23.4) | - | ||
| HER2+/ER- | - | 3 (33.3) | ||
| TNBC | - | 6 (66.7) | ||
DC-NST (invasive ductal carcinom—non special type), ILC (invasive lobular carcinoma). * Student’s t-test.