Table 2.
Association of AR/ER ratio with clinico-pathological characteristics of ER+ cases. Classification by AR/ER ratio of ER+ cases was concordant using both IHC and qPCR methods. AR: androgen receptor; ER: estrogen receptor.
| Characteristics | AR/ER < 2 n (%) |
AR/ER > 2 n (%) |
P Value (Fisher Test) |
|
|---|---|---|---|---|
| Total number of patients | 37 (78.7) | 10(21.3) | - | |
| Median Age (Interval) | 62 (35–79) | 65 (47–82) | 0.309 * | |
| Grading | 1 | 3 (8.1) | 1 (10) | 0.215 |
| 2 | 18 (48.6) | 2 (20) | ||
| 3 | 43 (16.1) | 7 (70) | ||
| Tumor size | <20 mm | 12 (33.3) | 4 (40) | 0.485 |
| ≥20 mm | 24 (66.7) | 6 (60) | ||
| Metastatic Lymph nodes | 0 | 20 (54.1) | 2 (20) | 0.108 |
| 1–3 | 9 (24.3) | 5 (50) | ||
| >3 | 8 (21.6) | 3 (30) | ||
| Vascular invasion | No | 4 (10.8) | 3 (30) | 0.155 |
| Yes | 33 (89.2) | 7 (70) | ||
| PgR | <20% | 26 (70.3) | 4 (40) | 0.136 |
| ≥20% | 11 (29.7) | 6 (60) | ||
| Ki-67 | <20% | 12 (32.4) | 2 (20) | 0.366 |
| ≥20% | 25 (67.6) | 8 (80) | ||
| HER2 Status |
Negative | 32 (86.5) | 4 (40) | 0.01 |
| Positive | 5 (13.5) | 6 (60) | ||
| ER% | Mean (interval) | 78 (2–99) | 21 (2–50) | <0.001 * |
| AR% | Mean (interval) | 70 (0–99) | 83 (50–100) | 0.319 * |
| IHC – Surrogate Subtype | Luminal A | 12 (32.4) | 0 (0) | 0.004 |
| Luminal B-Like (HER2-) | 20 (54.1) | 4 (40) | ||
| Luminal B-Like (HER2+) | 5 (13.5) | 6 (60) | ||
* Student’s t-test.